Motif ID: SOX{8,9,10}.p2

Z-value: 1.563


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
Sox10 20665 SRY-box containing gene 10
Sox8 20681 SRY-box containing gene 8
Sox9 20682 SRY-box containing gene 9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9chr11_+_1126435010.281.7e-04Click!
Sox8chr17_-_257075990.199.4e-03Click!
Sox10chr15_-_789947530.046.1e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_43552694 19.994 NM_009468
 Dpysl3
dihydropyrimidinase-like 3
chr1_-_82232392 17.466 Irs1
insulin receptor substrate 1
chr8_+_125935470 16.101 Tubb3
tubulin, beta 3
chr9_-_83040061 15.577 NM_026122
NM_175074
 Hmgn3

high mobility group nucleosomal binding domain 3

chr1_+_45401659 14.393 Col3a1
collagen, type III, alpha 1
chr3_-_57651621 14.118 NM_019410
 Pfn2
profilin 2
chr19_-_40588193 13.676 Sorbs1
sorbin and SH3 domain containing 1
chr15_+_98465193 13.445 NM_007581
 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr1_+_45401303 13.047 Col3a1
collagen, type III, alpha 1
chr3_+_121160714 13.035 Cnn3
calponin 3, acidic
chr10_-_36858671 12.881 NM_008538
 Marcks
myristoylated alanine rich protein kinase C substrate
chr17_-_35975075 12.560 Tubb5
tubulin, beta 5
chr19_-_15999377 12.311 NM_177420
 Psat1
phosphoserine aminotransferase 1
chr9_-_49311823 12.174 Ncam1
neural cell adhesion molecule 1
chr4_+_134024234 12.156 NM_019641
 Stmn1
stathmin 1
chr19_-_40588235 12.140 Sorbs1
sorbin and SH3 domain containing 1
chr6_+_122463595 11.716 Mfap5
microfibrillar associated protein 5
chr1_-_194677940 11.469 NM_001177794
 Sertad4
SERTA domain containing 4
chr19_+_44368557 11.400 Scd2
stearoyl-Coenzyme A desaturase 2
chr18_-_16967754 10.953 Cdh2
cadherin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 117 entries
Enrichment   P-value GO Accession GO Term
5.91 2.05e-02 GO:0030239 myofibril assembly
5.48 4.80e-03 GO:0031032 actomyosin structure organization
4.68 1.11e-02 GO:0032272 negative regulation of protein polymerization
4.60 4.40e-06 GO:0055002 striated muscle cell development
4.10 2.12e-04 GO:0051494 negative regulation of cytoskeleton organization
4.04 5.68e-05 GO:0055001 muscle cell development
3.91 4.11e-02 GO:0031333 negative regulation of protein complex assembly
3.91 4.11e-02 GO:0048747 muscle fiber development
3.90 1.51e-07 GO:0051146 striated muscle cell differentiation
3.52 2.83e-03 GO:0007015 actin filament organization
3.41 1.02e-05 GO:0003012 muscle system process
3.31 8.15e-11 GO:0030036 actin cytoskeleton organization
3.25 1.76e-06 GO:0042692 muscle cell differentiation
3.17 2.70e-10 GO:0030029 actin filament-based process
3.10 2.38e-03 GO:0006936 muscle contraction
3.06 4.43e-02 GO:0007018 microtubule-based movement
2.97 5.50e-03 GO:0010639 negative regulation of organelle organization
2.75 7.24e-14 GO:0007010 cytoskeleton organization
2.66 2.06e-05 GO:0051129 negative regulation of cellular component organization
2.64 2.36e-05 GO:0000087 M phase of mitotic cell cycle

Gene overrepresentation in compartment category:

Showing 1 to 20 of 72 entries
Enrichment   P-value GO Accession GO Term
11.55 4.54e-02 GO:0030934 anchoring collagen
6.74 1.24e-02 GO:0031672 A band
4.40 6.69e-04 GO:0042641 actomyosin
4.23 5.82e-03 GO:0001725 stress fiber
3.94 1.28e-02 GO:0032432 actin filament bundle
3.75 1.05e-02 GO:0005884 actin filament
3.49 1.29e-02 GO:0005901 caveola
3.38 1.98e-06 GO:0043292 contractile fiber
3.33 9.03e-06 GO:0044420 extracellular matrix part
3.31 1.23e-03 GO:0005924 cell-substrate adherens junction
3.30 6.56e-05 GO:0044449 contractile fiber part
3.29 2.12e-05 GO:0030016 myofibril
3.14 1.59e-03 GO:0030017 sarcomere
3.11 9.62e-03 GO:0005925 focal adhesion
3.11 4.92e-02 GO:0031674 I band
3.08 3.66e-03 GO:0030055 cell-substrate junction
3.03 1.36e-02 GO:0005604 basement membrane
3.02 7.79e-05 GO:0005912 adherens junction
2.88 2.07e-10 GO:0015629 actin cytoskeleton
2.87 1.47e-04 GO:0070161 anchoring junction

Gene overrepresentation in function category:

Showing 1 to 20 of 29 entries
Enrichment   P-value GO Accession GO Term
7.88 2.35e-02 GO:0003785 actin monomer binding
7.22 4.43e-02 GO:0005159 insulin-like growth factor receptor binding
3.78 8.54e-04 GO:0019902 phosphatase binding
3.41 4.70e-02 GO:0019903 protein phosphatase binding
3.26 2.31e-04 GO:0008201 heparin binding
3.19 6.99e-06 GO:0005539 glycosaminoglycan binding
3.04 7.64e-06 GO:0001871 pattern binding
3.04 7.64e-06 GO:0030247 polysaccharide binding
2.79 4.59e-10 GO:0003779 actin binding
2.56 5.33e-14 GO:0008092 cytoskeletal protein binding
2.42 9.48e-12 GO:0019904 protein domain specific binding
2.33 3.98e-02 GO:0004721 phosphoprotein phosphatase activity
2.02 6.49e-03 GO:0019900 kinase binding
2.01 3.74e-02 GO:0019901 protein kinase binding
1.88 1.77e-02 GO:0032403 protein complex binding
1.84 1.00e-03 GO:0005509 calcium ion binding
1.81 1.79e-06 GO:0019899 enzyme binding
1.65 6.48e-04 GO:0030234 enzyme regulator activity
1.59 4.54e-37 GO:0005515 protein binding
1.47 4.12e-02 GO:0005102 receptor binding